|
KMID : 0613820040140020280
|
|
Journal of Life Science
2004 Volume.14 No. 2 p.280 ~ p.285
|
|
|
Reduction of Oxidative Stress by Chondroitin Sulfate in the Ovariectomy-Induced Aging Rat
|
|
Lee Jin-Young
Ha Bae-Jin
|
|
|
Abstract
|
|
|
|
The ovarian hormone-deficiency induced ovariectomy rat is widely used as an aging model due to its practicality, convenience, and cost effectiveness. The surgically ovariectomized rat induces reactive oxygen species (ROS) generation like aging phenomena. Free oxygen radicals have been proposed as important causative agents of aging. The purpose of this study was to investigate the effect of chondroitin sulfate (CS) to prevent ovariectomy (OVX)-induced oxidative stress. The OVX rats were given intraperitoneally CS at doses of 100 mg/kg and 200 mg/kg daily for fifteen weeks. Malondialdehyde (MDA) levels were determined as well as the activities of superoxide dismutase (SOD), catalase (CAT), reduced-glutathione (GSH), oxidized-glutathione (GSSG), glutathione peroxidase (GPx) in the liver. The liver antioxidative enzyme activity was elevated while MDA concentration decreased in all CS treated animals. The results demonstrated that CS reduced oxidative stress in a dose dependent manner. These results suggest that CS might be a useful candidate for antioxidative reagent.
|
|
|
KEYWORD
|
|
|
Chondroitin sulfate, Reactive oxygen species, Ovariectomy, Malondialdehyde, Antioxidative stress
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|